DEUBIQUITINASES IN HEMATOLOGICAL MALIGNANCIES

Deubiquitinases in hematological malignancies

Abstract Deubiquitinases (DUBs) are enzymes that control the stability, interactions or localization of most cellular proteins by removing their ubiquitin modification.In recent years, some DUBs, such Moderator Covers as USP7, USP9X and USP10, have been identified as promising therapeutic targets in hematological malignancies.Importantly, some pote

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